Which of the following does NOT qualify as a criterion for psychoactive substance dependence according to the DSM IV-TR?

The criterion that does not qualify as a symptom of psychoactive substance dependence according to the DSM IV-TR is characterized by a marked lack of initiative, interest, or energy. This is more related to symptoms of psychological or mood disorders, such as depression, rather than being a direct indicator of substance dependence.

In the context of substance dependence, the other criteria listed focus on specific behaviors associated with the misuse of substances. For instance, taking a substance in larger amounts than intended indicates a loss of control over usage, which is a core aspect of dependence. Frequent intoxication despite significant responsibilities emphasizes the negative impact of substance use on important areas of life. Lastly, making unsuccessful efforts to cut down on use reflects an awareness of the problem and a struggle with controlling substance intake, which directly ties to the concept of dependence.

In summary, while a lack of initiative could be a result of substance abuse, it is not a defining criterion for dependence within the DSM IV-TR framework.